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Slide 1: American Society for Reproductive Immunology ASRI 2009 29th Annual Meeting June 5-9, 2009 Caribe Royale Hotel and Convention Center, Orlando, Florida Tentative Program as of 4-30-2009
Slide 2: PROGRAM Organized by the ASRI CONTENTS ASRI Organization Officers and Council Members President and Meeting Chair’s Welcome Past Meeting and Chairs Meeting Information Meeting Venue Learning Objectives On Site Registration/Hours Continuing Medical Education Credits (CME) ASRI Award Educational Grants and Meeting Sponsors Annual Meeting Calendar Meeting Program 2
Slide 3: American Society for Reproductive Immunology 2009 Officers: President: Charles Wira, Ph.D. Lebanon, NH Vice President: Udo Markert, M.D., Ph.D., Jena, Germany President-Elect: Surendra Sharma, M.D., Ph.D., Providence, RI Treasurer: Gil Mor, M.D., Ph.D. New Haven, CT Secretary: Silvia Daher, Ph.D., Sao Paulo, Brazil Immediate Past President: Joanne Kwak-Kim, M.D. Chicago, IL Council Members: Vikki Abrahams, Ph.D. New Haven, CT Peter Ahlering, M.D. Creve Coeur, MO Richard Bronson, M.D. Stonybrook, NY Mary Brown, Ph.D. Gainesville, FL Charu Kaushic, Ph. D Hamilton, Ontario, Canada 3
Slide 4: ABSTRACT PRESIDENT’S WELCOME I would like to welcome you to Orlando to the 29th annual meeting of our society. We can expect to be joined by clinicians and basic scientists to discuss contemporary topics in reproductive immunology and share their research results concerning important new developments in the field. In continuation of what we have started last year with a huge success, we are offering a Post Graduate course to young investigators and trainees. The students and mentors Round-Table-Discussions promise to be another highlight of our meeting. The President’s Symposium features current critical topic on human immunodeficiency virus. I expect this meeting to promote intellectual exchange in the various disciplines of reproductive immunology as well as provide mentorship for new scientists interested in reproductive immunology. I believe that after you have read the program you will would to attend every presentation. I look forwarding to seeing you in Orlando– the perfect destination for our meeting. Charles Wira, Ph.D. President, American Society for Reproductive Immunology MEETING CHAIR’S WELCOME Welcome to the 2009 Annual Meeting of the American Society for Reproductive Immunology. This year’s program is comprehensive and reflects advances both in reproduction and immunology. A balanced mix of new developments in clinical and basic research in the field of reproductive immunology will provide a wealth of information and scientific stimulation for attendees. The facilities in Orlando are outstanding and we would like to thank all who helped to make this meeting successful, especially to University of Florida for assisting in preparation of this meeting and generous support. We look forward to an exciting meeting where we will see old friends and make new ones. Thank you all for your contributions and support. Peter Hansen, Ph.D. Chair, 29th Annual Meeting 4
Slide 5: PAST ASRI MEETINGS AND CHAIRS Year 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 Site and Location Mount Sinai Medical Center, NY Mount Sinai Medical Center, NY Bowman Gray, Winston-Salem, NC University of Utah, Salt Lake City, UT Duke University, Durham, NC University of Michigan, Ann Arbor, MI Toronto, Canada1 Indianapolis, IN University of Maine, Prout's Neck, ME University of Maine, Prout's Neck, ME Chicago, IL University of Virginia, Charlottesville, VA University of South Carolina, Charleston,SC Denver2 Thomas Jefferson University, Philadelphia Washington, DC1 University of Tennessee University of British Columbia Finch University of Health Science/ The Chicago Medical School Cooperstown, NY Chair N. Gleicher N. Gleicher J. Gudson, Jr. J. R. Scott S. Gall A. E. Beer D. Clark C. Coulam N. S. Rote N. S. Rote, N. Gleicher J. Heff S. Mathur J. Head B. Smith C. Coulam D. Torry M. Stephenson K. Beaman S.P.Mathur/ S.D.Michael P.J. Hansen University of Florida Finch University of Health Sciences/ The Chicago Medical School J.Y.H. Kwak-Kim 2002 Finch University of Health Sciences/ The Chicago Medical School J.Y.H. Kwak-Kim 2003 Yale University Gil Mor 2004 University of Southern Illinois, M. Cooper/ Saint Louis, MO P. Ahlering 2005 Brown University, Providence, IL S. Sharma G. Yeaman 2006 Vanderbilt University, Nashville, TN 2007 McMaster University, Ontario, Canada C. Kaushic 2008 Rush University, Chicago, IL J. Lubosrky 1 Held jointly with the International Society for Immunology of Reproduction 2 Held jointly with the American Association of Immunologists 5
Slide 6: MEETING VENUE The conference headquarters, the Caribe Royale Hotel and Convention Center, is located central to all of Orlando's exciting world-famous attractions, just off I-4 and only minutes from theme parks, shopping and the Orlando International Airport. It is the largest all-suite resort in Florida. Guests can enjoy being close to major leisure activities, including factory outlet shopping at two outlet malls within 3 miles, and Walt Disney World Theme Parks®, Downtown Disney®, and Universal Studios, all within 10 miles. The Caribe Royale also offers business services, three restaurants and a lounge onsite, fitness center, two tennis courts, two outdoor pools, plus golf courses nearby. For your dining pleasure, you can choose Montego's for exquisite continental cuisine, Cafe Largo Pizzeria and Deli, or Calypso's for casual food in the pool area. LEARNING OBJECTIVES The objectives of the 28th Annual Meeting of the American Society for Reproductive Immunology are to bring together clinicians and basic scientists to: - review causes and methods of prevention of HIV. - gain insights into causes and prevention of preterm births. - understand the role of the immune system in the male reproductive tract. - evaluate the latest concepts in understanding endometrial function including the role of stem cells and miRNA. - become knowledgeable of funding sources for reproductive immunology. - appreciate the impact of chlamydial infections on female fertility and health. - recognize the interaction between autoimmune diseases and pregnancy. - appreciate new experimental models for understanding disruptions in pregnancy. - become aware of the properties and function of gamma-delta T cells in the uterus. - review new developments in preeclampsia. 6
Slide 7: PROGRAM COMMITTEE Conference Chair Chair: Hansen, Peter, Ph.D., Dept. of Animal Sciences, University of Florida, Gainesville, FL. Co-Chair: Brown, Mary, Ph.D., Dept. of Pathobiology, University of Florida, Gainesville, FL. Program Committee Abrahams, Vikki, Ph.D., Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT. Cooper, Morris, Ph.D. Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield, IL. Daher, Silvia, Ph.D., Department of Obstetrics, UNIFESP-EPM, Sao Paulo, Brazil Kaushic, Charu, Ph.D., Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. Kunz, Heinz, Ph.D., University of Pittsburg, Pittsburg, PA. Kwak-Kim, Joanne, M.D., MPH., Women’s Health Center, Chicago Medical School, North Chicago, IL Mor, Gil, M.D., Ph.D., Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT Ott, Troy, Ph.D. Animal and Veterinary Sciences Department, University of Idaho, Moscow, ID Peltier, Morgan, Ph.D., Lead Scientist-Perinatology Research Laboratory, Winthrop University Hospital, Mineola, NY. Sharma, Surendra M.D., Ph.D., Department of Pediatrics, Brown University, Women and Infant’s Hospital of RI, Providence, RI. Shibahara, Hiroaki, M.D., Ph.D., School of Medicine, Jichi Medical University, Shimotsuke, Japan Wira, Charles R. Ph.D. Department of Physiology, Dartmouth Medical School, NH ABSTRACT ON-SITE MEETING REGISTRATION Post graduate course, all scientific sessions, poster session, round table and meetings will be held at the Caribe Royal Hotel and Convention Center. Entry to all sessions requires registration and the wearing of a name badge. Registration will be conducted at the ASRI registration desk, which will be at The Caribbean Registration Desk. REGISTRATION HOURS Friday, June 5, 2009 11:00am – 1:00pm Saturday, June 6, 2009 7:30am – 9:00am Saturday, June 6, 2009 9:00am – 4:00pm Sunday, June 7, 2009 7:30am – 4:00pm Monday, June 8, 2009 7:30am – 12:00pm Tuesday, June 9, 2009 7:30 – 12:00pm 7
Slide 8: ACCREDITATION AND DESIGNATION STATEMENT This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Rosalind Franklin University of Medicine & Science and American Society for Reproductive Immunology. Rosalind Franklin University of Medicine & Science is accredited by the ACCME to provide continuing medical education for physicians. Rosalind Franklin University of Medicine & Science designates this educational activity for a maximum of 18.0 AMA PRA Category 1 Credit(s) TM. Physicians should only claim credit commensurate with the extent of their participation in the activity. ASRI AWARDS The American Society for Reproductive Immunology presents three awards at its annual meeting: 1. The Blackwell Munksgaard Award is presented annually to a senior investigator who has made outstanding contributions to the area of reproductive immunology. Contributions can be in the area of clinical or basic research. Awardees do not need to be members of the ASRI. 2. The J. Christian Herr is given annually to a member of the ASRI or ISIR, typically in the first 10–15 years beyond accepting a faculty position, who has made outstanding achievements in basic or applied research in reproductive immunology, particularly for investigators involved in technology transfer. The J. Christian Herr award was established by a past president of the ASRI to acknowledge the dedication of his father to invention, innovation and entrepreneurship through decades of volunteerism in the Service Core of Retired Executives (SCORE), a program of the Small Business Administration. The spirit of the award may be found in the words of Louis Pasteur, ‘‘There is no true distinction between fundamental and applied science, there is only science in the cause of humankind.’’ 3. The Dr. John Gusdon Memorial New Investigator Award is awarded to a new investigator with trainee status (graduate student, postdoctoral scientist, or resident) who has made a significant contribution by presenting an outstanding research paper during the annual meeting of the ASRI. This award is given annually in memory of Dr. John Gusdon, a founding member of the ASRI, and an advocate of student participation in ASRI meeting. 4. The ASRI also awards a variety of travel grants to support travel of trainees to the Annual Meeting. One of these awards, the Alan E. Beer Memorial Travel Grant, is specifically awarded to support travel for a clinical scientist in training status. 8
Slide 9: EDUCATIONAL GRANTS AND MEETING SPONSORS ASRI acknowledges the following organizations and sponsors for their generous financial support of ASRI 2009 American Autoimmune Related Diseases Association EMD Serono National Institutes of Health Office of Research Agricultural Experiment Station College of Veterinary Medicine Health Science Center 9
Slide 10: VisualSonics Women and Infants Hospital of Rhode Island Dr. Surendra Sharma USDA 10
Slide 11: ANNUAL MEETING CALENDAR Post Graduate Course (Boca 4) Friday, June 5, 2009- Saturday, June 6, 2009 Friday, June 5, 2009 11:00am–1:00pm Registration 1:00pm–6:00pm Post graduate course 6:00pm−8.00pm Dinner with the faculty Saturday, June 6, 2009 7:30am−9:00am Registration 8:00am–12:00pm Post graduate course II Scientific Program ⁄ Plenary Session (Caribbean 6 & 7) Wednesday, June 6, 2008- Tuesday, June 9, 2009 Saturday, June 6, 2009 9:00am–1:00pm Annual Meeting Registration 1:00pm–1:30pm Opening Remarks and Welcome 1:30pm–3:00pm Presidential Symposium Human Immunodeficiency Virus 3:30pm–4:30pm Plenary Session 1 Preterm Birth 4:30pm–7:00pm Opening Reception (Poolside) Sunday, June 7, 2009 7:00am−8:00am Editorial Board Meeting (Boca 4) 7:30am−4:00pm Registration 9:00am−11:00am Poster set up (Caribbean 5) 9:00am–10:00am Plenary Session 2 Male Reproductive Immunology 10:30am–12:00pm Plenary Session 3 Novel Concepts of Endometrial Function 12:00pm−2:00pm Executive Council Meeting (Boca 1) 12:00pm−2:00pm Luncheon Workshop Funding Opportunities for Reproductive Immunology Research (Caribbean 6 & 7) 2:00pm–3:15pm 5 Gusdon Award Finalist Oral Presentation 3:15pm–3:30pm Break 3:30pm–5:30pm Poster Session/Wine and Cheese Reception (Caribbean 5) Monday, June 8, 2009 7:30am–12:00pm Registration 8:30am–10:00am Plenary Session 4 Chlamydial Infections 11
Slide 12: 10:00am–12:00pm Plenary Session 5 Sexually Transmitted Diseases 5:00pm Poster Tear-Down (Caribbean 5) Tuesday, June 9, 2009 7:30 am−12:00pm Registration 8:30am–10:00am Plenary Session 6 Autoimmunity and Pregnancy 10:00am–12:00pm Plenary Session 7 New Models for Pregnancy Perturbations 1:30pm–2:15pm J. Christian Herr Lecture 2:15pm–4:00pm Plenary Session 8 Pregnancy and Preeclampsia 4:00pm−5:30pm General Business Meeting Awards Banquet (Caribbean 5) 6:30pm−9:00pm 12
Slide 13: 29th Annual Meeting American Society for Reproductive Immunology June 5-9, 2009 Caribe Royale Hotel and Convention Center, Orlando, Florida JUNE 5, 2009 Postgraduate Course Boca 4 In Vivo Approaches and New Biology at the Maternal-Fetal Interface: From Small and Large Animals to Humans (Organizers: S. Sharma, G. Chaouat, and D.C. Clark) 11:00 AM Registration through 1:00 PM 1:00 PM Shathiyah Kulandavelu, University of Toronto. Ultrasonic imaging of pregnant rodents. 1:45 PM P. J. Hansen, University of Florida. Ruminant models for the study of pregnancy. 2:30 PM Surendra Sharma, Women and Infants Hospital-Brown University. Methods and models for preterm birth and pre-eclampsia. 3:15 PM Refreshments 3:45 PM Demonstration of ultrasound by VisualSonics (through 6:00 PM) 6:00 PM Dinner with Faculty (Boca 5 & 6) Stress and inflammation in pregn-ancy: Brain and Body connections. 8:45 AM G. Chaouat, INSERM, Clamart, France. Systemic vs. local immunity in reproduction: Comparative analysis in humans and mice. Refreshments C. Marsit, Brown University. Epigenetics and imprinting in placenta. M. Soares, Univesity of Kansas Medical Center. Adaptations at the maternal-fetal interface. Steve Palmer, EMD Serono Research Institute. Drug discovery research for implantation failure. 29th Annual Meeting 9:00 AM Registration through 4:00 PM Opening Ceremony Caribbean 6 & 7 1:00 PM Brown, Hansen, et al. Opening remarks 9:30 AM 10:00 AM 10:45 AM 11:30 AM JUNE 6, 2009 Postgraduate Course Boca 4 In Vivo Approaches and New Biology at the Maternal-Fetal Interface: From Small and Large Animals to Humans (Organizers: S. Sharma, G. Chaouat, and D.C. Clark) 7:30 AM 8:00 AM Registration through 9:00 AM P. Arck, McMaster University. 1:15 PM Presidential Symposium – Human Immunodeficiency Virus Caribbean 6 & 7 C.R. Wira, Chair Opening remarks, Wira 13
Slide 14: 1:30 PM Morgane Bomsel, Cochin Institute. Physiopathology of the sexual transmission of HIV. Ashley Haase, University of Minnesota Medical School. HIV-1 transmission to women: lessons from the SIV-rhesus macaque model. Robin J. Shattock, St. George’s University of London. Creating barriers to mucosal HIV infection: chemical, innate and adaptive. 2:00 PM Plenary Session 2 Male Reproductive Immunology Caribbean 6 & 7 Evangelos Ntrivalas, Rosalind Franklin University and Stefan Neubeck, FriedrichSchiller-Universität, Chairs 9:00 AM Maciej Kurpisz, Polish Academy of Sciences. Strategies for identification of new sperm entities for possible immunocontraception 9:30 AM Richard Bronson, Stony Brook University Medical Center. Roles of vitronectin and C1q in fertilization - a tale of two proteins 10:00 AM Refreshments Plenary Session 3 Novel Concepts of Endometrial Function Caribbean 6 & 7 Troy Ott, Pennsylvania State University, and Satyan Kalkunte, Brown University, Chairs 10:30 AM Caroline Gargett, Monash University. Endometrial stem/progenitor cells and endometrial regeneration. Nasser Chegini, University of Florida. miRNAs and their regulatory function in female reproductive tract tissues in normal and disease states. Herington, JL et al., Southern Illinois University School of Medicine and University of Tennessee College of Medicine. Microarray analysis of differential uterine gene expression between interleukin-15 wild-type and knockout mice. Padua, MB and Hansen, PJ. University of Florida, Changes in expression of cell-cycle related genes in PC-3 prostate cancer cells caused by ovine uterine serpin. Lunch through 2:00 PM Executive Council Meeting through 2:00 PM (Boca 1) 2:30 PM 3:00 PM Refreshments Plenary Session 1 Preterm Birth Caribbean 6 & 7 Gil Mor, Yale University, and NaYoung Kim, Chairs 3:30 PM Morgan Peltier, Winthrop University Hospital, Immunomodulatory treatments for preventing preterm birth. 4:00 PM Emmet Hirsch, Dept. of Obstetrics & Gynecology, NorthShore University HealthSystem and Feinberg School of Medicine, Northwestern University. The role of toll-like receptor signaling in preterm labor. Opening Reception Poolside (Atrium East in case of inclement weather) 4:30 PM Reception through 7:00 PM 11:00 AM 11:30 AM JUNE 7, 2009 7:00 AM AJRI Editorial board meeting through 8:00 AM (Boca 4) 7:30 AM Registration through 4:00 PM 9:00 AM Poster set up through 11:00 AM (Caribbean 5) 11:45 AM 12:00 PM 12:00 PM 14
Slide 15: Luncheon Workshop Funding Opportunities for Reproductive Immunology Research Caribbean 6 & 7 P.J. Hansen, Chair 12:00 PM Koji Yoshinaga, National Institutes of Health. NIH funding opportunities for reproductive immunologists. Michael Katz, March of Dimes. Funding opportunities at the March of Dimes. Roundtable discussion from the Audience 7:30 AM Infants Hospital, Providence, RI and Dartmouth Medical School. VEGF C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. 3:15 PM Break Poster Session/Wine and Cheese Reception Caribbean 5 3:30 PM Posters (until 5:30 PM) 12:30 PM 1:00 PM JUNE 8, 2009 Registration through 12:00 PM Gusdon Award Finalist Presentations Caribbean 6 & 7 Mary Brown, University of Florida, Chair 2:00 PM Friebe, A., et al. Charité – Universitätsmedizin Berlin, McMaster University and University of Edinburgh. Psychological stress requires microbial products to cause pregnancy loss in mice. Solano, M.E., et al., Charitè University Medicine Berlin, McMaster University, UBACONICET, University College London, and University of Edinburgh, Edinburgh,UK. Fetal origin of adult disease: insights on mechanistic cues and therapeutic targets arising from a mouse model. Racicot, K.E., et al., Pennsylvania State University. Characterization of an MX1positive population of exosomes secreted by uterine glandular epithelial cells. Cardenas, I., et al. Yale University. Inflammation triggered by TLR3 activation disturbs the balance of angiogenic factors in placenta. Kalkunte, S., et al., Women and Plenary Session 4 Chlamydial Infections Caribbean 6 & 7 Hong-Nerng Ho, National Taiwan University Hospital, and Lilian Oliveira, University of Florida, Chairs 8:30 AM Gary Entrican, Moredun Research Institute. Chlamydial persistence, immunological paradigms and the problem of ovine enzootic abortion. 9:00 AM Priscilla B. Wyrick, J.H. Quillen College of Medicine, East Tennessee State University. Estrogen enhances Chlamydia trachomatis genital infection. 9:30 AM Nazli, A., et al., McMaster University. HIV-1 exposure induces TNF-α production by polarized genital and intestinal epithelial monolayers leading to direct impairment of their barrier function. 9:45 AM Arase, T., et al., Keio University Hospital, Shinjuku, Tokyo, UDPglucose and its receptor P2RY14 as a novel innate immunity in the female reproductive tract. 10:00 AM Refreshments 2:15 PM 2:30 PM 2:45 PM 3:00 PM 15
Slide 16: Plenary Session 5 Sexually Transmitted Diseases Caribbean 6 & 7 Charu Kaushic, McMaster University, and Jennifer Herington, Southern Illinois University School of Medicine, Chairs 10:30 AM Kevin Ault, Emory University School of Medicine. Host responses to human papillomavirus: current knowledge and future research needs 11:00 AM Betsy Herold, Albert Einstein College of Medicine & Children’s Hospital at Montefiore. Role of soluble mucosal genital tract immunity in the overlapping epidemics of genital herpes & HIV. Ito, M., et al., Toyama, Japan and Hatay, Vietnam. Interleukin-17 (IL-17) and tumor necrosis factor-α synergistically increase IL-8 production by amniotoic methenchymal cells in preterm delivery cases with chorioamnionitis. Patel, M.V., et al., Dartmouth Medical School. Expression of intracellular antiviral genes in human uterine primary epithelial cells in response to stimulation by viral agonists. Lunch through 1:30 PM Florida Explorations 12:00 PM Free Time to Tour Orlando and Central Florida, Lounge at the Pool, etc. Poster Tear-Down (Caribbean 5) Joanne Kwak-Kim, Rosalind Franklin University, and Karen Racitot, Pennsylvania State University, Chairs 8:30 AM Vikki Abrahams, Yale University, Effects of antiphospholipid antibodies on trophoblast function and survival. Megan E. B. Clowse, Duke University, How rheumatologic disease changes pregnancy... and vice versa. Arroyo, J.A., et al. University of Colorado Denver and University of Texas Health Science Center at San Antonio. Decreased pERK, but not p-JNK or p-AKT at term is associated with increased apoptosis and caspase 3 following maternal nutrient reduction in the baboon placenta (MNR). Chernyshov, V., et al., Institute of Pediatrics, Obstetrics and Gynecology, Kiev, Reproductive Clinic Nadia, Kiev, and National Medical Academy for Postgraduate Education, Kiev. Th1 and Th2 parameters in women with IVF failure characterized by elevated NK cytotoxicity and antiphospholipid antibodies. Tea/coffee break 9:00 AM 9:30 AM 11:30 AM 9:45 AM 11:45 AM 10:00 AM 12:00 PM Plenary Session 7 New Models for Pregnancy Perturbations Caribbean 6 & 7 Silvia Daher, Universidade Federal de São Paulo, and Maria Padua, University of Florida, Chairs 10:30 AM Kevin Sinclair, University of Nottingham. Developmental origins of health and disease: Periconceptional diet and epigenetic programming in the oocyte and preimplantation embryo. Thomas R. Hansen, Colorado State University. BVDV alters maternal blood cell interferon 5:00 PM JUNE 9, 2009 7:30 AM Registration through 12 PM 11:00 AM Plenary Session 6 Autoimmunity and Pregnancy Caribbean 6 & 7 16
Slide 17: stimulated genes and chemokine receptor signaling associated with establishment of persistent fetal viral infection. 11:30 AM Karen J. McDowell, University of Kentucky. The role of caterpillars in mare reproductive loss syndrome – a model for environmental causes of abortion. Lunch through 1:30 PM and induces their rapid apoptosis. 4:00 PM General Business Meeting (held through 5:30 PM) 6:30 PM Awards Banquet (Caribbean 5) 12:00 PM J Christian Herr Lecture Caribbean 6 & 7 P.J. Hansen, Unviversity of Florida, Chair 1:30 PM Lucia Mincheva-Nilsson, Umeå University. Placenta-derived exosomes: from biogenesis to immunomodulatory role in pregnancy. Plenary Session 8 – Pregnancy and Preeclampsia Caribbean 6 & 7 Vikki Abrahams, Yale University, and Jessica Thaxton, Brown University, Chairs 2:15 PM Kirk Conrad, University of Florida. Relaxin and circulatory adaptations to pregnancy. 2:45 PM Ananth Karumanchi, Harvard Medical School, Angiogenic factors and preeclampsia. 3:15 PM Lai, Z et al., Women & Infants' Hospital of Rhode Island. Pregnancy-specific effects of hypoxia: a mouse model for preeclampsia. 3:30 PM Iwasawa, Y., et al., University of Tokyo. A possible pathogenic mechanism of recurrent miscarriage associated with β2 glycoprotein I-dependent antiphospholipid antibody through the function of CD1d. 3:45 PM Hayakawa, S., et al., Nihon University School of Medicine, University of Tokyo and Yale University. H3N2 influenza A virus replicates in immortalized human first trimester trophoblast cell lines 17
Slide 18: POSTER SESSION June 7, 3:30 – 5:30 PM Caribbean 5 Posters should be put up from 9:00 – 11:00 AM on June 7 and taken down by 5:00 PM on June 8 Pregnancy Failure and Complications S-1 Chaouat, GCP1, Ledée, N1, Petitbarat, M1, Bulla, R2, Mas, AE1, Dubanchet, S1, Tedesco, F2 .1 INSERM U782, Clamart, 92, France, 2 University of Trieste, Trieste, Trieste, Italy. Early regulators of early abortion. Arroyo, JA1, Li, C2, Schlabritz-Loutsevitch, N2, McDonald, T2, Nathanielsz, P2, Galan, HL1. 1 University of Colorado Denver, Aurora, Colorado, USA, 2 University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA. Decreased p-ERK, but not p-JNK or p-AKT at term is associated with increased apoptosis and caspase 3 following maternal nutrient reduction in the baboon placenta (MNR). Yang, KM1, 3, Nitrivalas, E2, Cho, HJ1, Kim, NY1, Beaman, K2, Gilman-Sachs, A2, KwakKim, J1,2 . 1 Reproductive Medicine, Department of Obstetrics and Gynecology and, 2 Department of Microbiology and Immunology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science , North Chicago, IL, USA. T cell activation and T helper 1 immunity in women with reproductive failures. Kim, NY1, Yang, KM1, 2, Cho, HJ1, Kwak-Kim, J1. 1 Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University, North Chicago, IL, USA, 2 Department of OB & Gyn, Cheil General Hospital & Women’s Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures. Park, DW1, Lee, HJ1, Park, CW1, Song, IO1, Kang, IS1, Hong, SR1, Kwak-Kim , J2, Yang, KM1. 1 Cheil General Hospital & Women’s Healthcare Center, Seoul, Korea, 2 The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Decidual NK (dNK) cells are correlated with peripheral blood NK (pNK) cells in women with recurrent miscarriages. Lee, SK1, Kim, JY1, Yang, KM2, Gilman-Sachs, A3, Kwak-Kim, J2,3. 1 Dept. of Ob/Gyn Konyang University, Daejeon, Korea, 2 Reproductive Medicine, Dept. of Ob/Gyn, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, N. Chicago, IL, USA, 3 Department of Microbiology and Immunology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science , North Chicago, IL, USA. Th17 cells seem to be affected by presence of autoantibodies and thrombophilia in women with recurrent spontaneous abortion and multiple implantation failures. Chen, JS1, Chen, HF2, Ho, HN1,2. 1 Graduate Institute of Immunology NTU, Taipei, Taiwan, 2 Department of Obstetrics and Gynecology NTUH, Taipei, Taiwan. The expression of Decoy receptor 3 is significantly lower in decidua from anembryonic pregnancies than that from normal pregnancies. Scarpellini, F, Sbracia, M. CERM, Rome, Italy. Aspirin versus aspirin plus heparin in the treatment of women with habitual abortion and positive to anticardiolipin at low or moderate levels: a controlled trial. Ahn, HK2, Kim, JK1, Yang, KM2, Kim, MH2, Jung, JH2, Choi, JS2, Han, JY2, Rheu, HM2, S-2 S-3 S-4 S-5 S-6 S-7 S-8 S-9 18
Slide 19: Kim, MY2, Yang, JH2. 1 The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL , USA, 2 Cheil General Hospital & Women’s Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea. Obstetric outcomes in women with recurrent spontaneous abortions (RSA) of immune etiology who were successfully treated with intravenous immunoglobulin G. S-10 Leavenworth, JD1, Groesch, KA1, Hu, X1, Malm, SW1, Torry, RJ2, Abrams, RM1, Torry, DS1. 1 Southern Illinois University School of Medicine, Springfield, IL, USA, 2 Drake University, Des Moines, IA, USA. Evidence of promyelocytic leukemia (PML) protein dysregulation in preeclamptic placenta; potential implications for impaired angiogenesis. Fukui, A, Nakamura, R, Yamada, K, Fukuyama, A, Kimura, H, Yamamoto, Y, Tanaka, K, Ozaki, T, Fujii, S, Mizunuma, H. Hirosaki University, Hirosaki, Aomori, Japan. The expression of natural cytotoxicity receptors and production of NK cell cytokines in pregnant women with pregnancy-induced hypertension. Cardenas, I, Aldo, P, Koga, K, Means, R, Lang, S, Mor, G. Yale University School of Medicine, New Haven, CT, USA. Subclinical viral infection in pregnancy leads to inflammatory process at the placenta with non-lethal fetal damage. Akyol, S1, Purisa, S2, Aydinli, K3. 1 Dept of Physiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey, 2 Dept of Biostatistics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey, 3 Dept of Gynecology and Obstetrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. NK, lymphocyte and cytokine levels in alcohol fed pregnant rats. Friebe, A1, 2, Hagen, E1, 2, Pliet, R1, Douglas, A3, Steinert, C1, Blois, S1, Clark, D4, Arck, P1,2. 1 Charité - Universitätsmedizin Berlin, Center for Internal Medicine and Dermatology, Berlin, Berlin, Germany, 2 Brain Body Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada, 3 Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, UK, 4 Departments of Medicine, Molecular Medicine & Pathology, Obstetrics & Gynecology, McMaster University, Hamilton, Ontario, Canada. Psychological stress requires microbial products to cause pregnancy loss in mice. Lai, Z, Kalkunte, S, Sharma, S. Women & Infants' Hospital of Rhode Island, Providence, RI, USA. Pregnancy-specific effects of hypoxia: a mouse model for preeclampsia. Xie, F1, 2, Turvey, SE1, 2, von Dadelszen, P1,2. 1 University of British Columbia, Vancouver, BC, Canada, 2 Child and Family Research Institute, Vancouver, BC, Canada. Toll-like receptor signalling: an emerging bridge between innate immunity and pre-eclampsia. Sudoma, I1, 2, Kremenska, Y1, Kremenskoy, M1, Chernyshov, V3, Masliy, Y1, Goncharova, Y1, Chornyj, V1. 1 Reproductive Medicine Clinic “NADIJA”, Kyiv, Ukraine, 2 National Medical Academy of Postgraduate Education named in honor of P.L.Shupyk, Kyiv, Ukraine, 3 Laboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology, Academy of Medical Science, Kyiv, Ukraine. Administration of intrauterine autologous peripheral blood mononuclear cells in patients with multiple implantation failures: Correlation with peripheral blood Th1/Th2 ratio and PBMN cell gene expression. Fraccaroli, L1, Larocca, L1, Calafat, M1, Lombardi, E2, Perez Leiros, C1, Ramhorst, R1 Immunopharmacology Laboratory, School of Sciences University of Buenos Aires, Buenos Aires, Argentina, 2 Instituto de Fertilidad IFER, Buenos Aires, Argentina. Deficiencies in VIP levels during the feto-maternal dialogue conditioned the pregnancy 1 S-11 S-12 S-13 S-14 S-15 S-16 S-17 S-18 19
Slide 20: outcome. S-19 Ito, M1, Nakashima, A1, Ina, S1, Okabe, M2, Bac, ND3, Yoneda, S1, Shiozaki, A1, Tsuneyama, K4, Nikaido, T2, Saito, S1. 1 Obstetrics and Gynecology, Toyama, Toyama, Japan, 2 Regenerative Medicine, Toyama, Toyama, Japan, 3 Anatomy, Hatay, Hatay, Vietnam, 4 Diagnostic Pathology, Toyama, Toyama, Japan. Interleukin-17(IL-17) and tumor necrosis factor synergistically increase IL-8 production by amniotoic methenchymal cells in preterm delivery cases with chorioamnionitis. Cardenas, I, Koga, K, Aldo, P, Mor, G. Yale University, New Haven, CT, USA. Inflammation triggered by TLR3 activation disturbs the balance of angiogenic factors in placenta. Thaxton, JE1, Murphy, SP2, Romero, R3, Sharma, S1. 1 Women and Infants’ Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA, 2 Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA, 3 Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, MD, USA. Preterm birth and placental cell death mediated by uterine NK cells in response to intrauterine pathogen delivery. Solano, ME1, 2, 3, Steinert, C1, Bruenhal, C1, 2, Hagen, E1, 2, Blois, SM1, 4, Motta, AB3, Douglas, AJ5, Arck, PC1,2. 1 Charitè University Medicine Berlin, Berlin, Germany, 2 Brain Body Institute, McMaster University , Hamilton, Ontario, Canada , 3 Center of Pharmacological and Botanical Studies-UBA-CONICET, Buenos Aires, Argentina, 4 University College London, London, UK, 5 Centre for Integrative Physiology, University of Edinburgh, Edinburgh,UK. Fetal origin of adult disease: insights on mechanistic cues and therapeutic targets arising from a mouse model. S-20 S-21 S-22 Other Reproductive Disorders S-23 Solano, ME1, 2, 3, Hagen, E1, 3, Motta, AB2, Arck, PC1,3. 1 Charitè University Medicine Berlin, Berlin, Germany, 2 Center of Pharmacological and Botanical Studies-UBACONICET, Buenos Aires, Argentina, 3 Brain and Body Institute, McMaster University , Hamilton , Canada. Insights from a novel mouse model for Polycystic Ovary Syndrome (PCOS): systemic inflammation and up-regulation of adhesion molecule expression in ovaries is associated with clinical symptoms. Scarpellini , F1, Sbracia, M2, Arduini, D1. 1 University of Tor Vergata, Rome, Italy, 2 CERM, Rome, Italy, Possible role of HSP in endometriosis progression. Mor, G, Fu, H, Holmberg, J, Visintin, I, Mor, L, Cano, C, Alvero, AB. Yale University School of Medicine, New Haven, CT, USA. Ovarian cancer stem cells can serve as vascular progenitors. S-24 S-25 Genetics S-26 Daher, S, Gueuvoghlanian Silva, BY, Oliveira, LS, Torloni, MR, Nakamura, MU, Mattar, R São Paulo Federal University, São Paulo, Brazil. Gestational diabetes and adiponectin +45 T/G gene polymorphism: preliminary results. Pendeloski, KPT, Lage, FC, Franchim, CS, Sass, N, Daher, S. São Paulo Federal University, São Paulo, São Paulo, Brazil. CTLA-4, CD28 and ICOS gene polymorphisms in women with preeclampsia: preliminary results. S-27 20
Slide 21: S-28 Daher, S1, Torloni, MR1, Gonçalves-Primo, A2, Ruecke, M3, Moron, AF1, Mattar, R1, Arck, P3. 1 Obstetric Department, São Paulo Federal University, São Paulo, Brazil, 2 Immunogenetics Division, São Paulo Federal University, São Paulo Brazil, 3 Division of Psycho-Neuro-Immunology, Charité, University Medicine Berlin, Berlin Germany. Genetic polymorphisms in normal versus abnormal pregnancy outcomes: pilot study. S-29 Franchim , CS, Sass , N, Pendeloski, KPT, Mattar, R, Daher, S. São Paulo Federal University, São Paulo, Brazil. Analysis of inflammatory polymorphisms in women with preeclampsia. Daher, S1, Gonçalves-Primo , A2, Torloni, MR1, Ruecke, M3, Moron, AF1, Mattar, R1, Arck, P3. 1 Obstetric Department, São Paulo Federal University, São Paulo, Brazil, 2 Immunogenetic Division, São Paulo Federal University, São Paulo, Brazil, 3 Division of Psycho-Neuro-Immunology, Charité, University Medicine, Berlin. Genetic polymorphisms, maternal body mass index and normal pregnancy outcome: pilot study. Park, CW1, Lee, HJ1, Kwak-Kim, J4, Park, SY2, Han, JY1, Koong, MK1, Song, IO1, Yang, KM1, 3. 1 Department of OB & Gyn, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea, 2 Laboratory of Medical Genetics, Cheil General Hospital & Women's Healthcare Center, Seoul, Korea. The role of methylenetetrahydrofolate reductase (MTHFR) C677T mutations in women with unexplained recurrent miscarriages; Does it have any effect on modulating immune response? Cho, HJ1, Yang, KM1, 2, Kim, NY1, Kwak-Kim, J1. 1 The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA, 2 Cheil General Hospital & Women’s Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. The influence of plasminogen activator inhibitor-1 (PAI-1) polymorphism on infertility and recurrent pregnancy loss. S-30 S-31 S-32 Autoimmunity S-33 Mulla, MJ1, Brosens, JJ2, Chamley, LW3, Paidas, MJ1, Abrahams, VM1. 1 Yale University School of Medicine, New Haven, CT, USA, 2 Imperial College London, London, UK, 3 University of Auckland, Auckland, New Zealand. Antiphospholipid antibodies limit trophoblast invasion and migration by reducing STAT3 activity. Iwasawa, Y, Kawana, K, Fujii, T, Nagamatsu, T, Matsumoto, J, Miura, S, Yamashita, T, Hyodo, H, Kozuma, S, Taketani, Y. The University of Tokyo, Tokyo, Japan. A possible pathogenic mechanism of recurrent miscarriage associated with β2 glycoprotein Idependent antiphospholipid antibody through the function of CD1d. Obayshi, S1, Ozaki, Y1, Sugi, T2, Kitaori, T1, Suzuki, S1, Sugiura, M1. 1 Nagoya City University , Nagoya, Aichi, Japan, 2 Tokai University, Isehara, Kanagawa, Japan. Antiphosphatidylethanolamine antibodies in patients with recurrent pregnancy losses. Go, I, Tatsuo, Y, Fumihisa , C, Yoishi, A, Akikazu, N, Soichiro, K, Takayuki, M. Nihon University, Tokyo, Japan. Effects of antiβ2-GPI antibody on PlGF, VEGF and sVEGFR1 production from cultured choriocarcinoma cell line. Shurshalina, AV, Sukhikh, GT, Perminova , SG, Demura, TA, Stankovich, EB. Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia. Autoimmune thyroiditis and infertility: the effect of antithyroid antibodies on endometrial receptivity. S-34 S-35 S-36 S-37 21
Slide 22: S-38 Shurshalina, AV, Sukhikh, GT, Perminova, SG, Demura, TA, Stankovich, EB. Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia. Autoimmune thyroiditis and endometrium: the role of thyroid antibodies in support of endometrial inflammation. Scarpellini, F, Sbracia, Ma. CERM, Rome, Italy. β-2 glycoptotein 1 antibodies in habitual abortion: role and clinical outcome of women positive to them. S-39 In Vitro Fertilization S-40 Chernyshov, V1, Sudoma, I2, 3, Donskoi, B1, Kostyuchik, A1, Masliy, Y2. 1 Institute of Pediatrics, Obstetrics and Gynecology, Kiev, Ukraine, Ukraine, 2 Reproductive Clinic Nadia, Kiev, Ukraine, Ukraine, 3 National Medical Academy for Postgraduate Education, Kiev, Ukraine, Ukraine. Th1 and Th2 parameters in women with IVF failure characterized by elevated NK cytotoxicity and antiphospholipid antibodies. Neubeck, S1, Hoppe, I1, Holzhauer, C2, Alunni-Fabbroni , M2, von Eggeling , F1, Starker, W1, Markert, UR1. 1 University Hospital Jena, Jena, Thuringia, Germany, 2 Olympus Life Science Research Europa, Munich, Bavaria, Germany. New methods for the analysis of follicular fluids. Roussev, RG1, Acacio, B2, Stamatkin, CW1, Singh, S2, Ramu, S1, Coulam, CB1,3. 1 CARI Reproductive Institute, Chicago, IL, USA, 2 Acacio Fertility Center, Laguna Niguel, CA, USA, 3 Rinehart Center for Reproductive Medicine, Evanston, IL, USA. Evaluation of soluble HLA-G threshold for embryo selection in IVF/ET. Ramu, S1, Goodman, C1, Stamatkin, CW1, Roussev, RG1, Coulam, CB1,2. 1 CARI Reproductive Institute, Chicago, IL, USA, 2 Rinehart Center for Reproductive Medicine, Chicago, IL, USA. Developing immuno-polymerase chain reaction (IPCR), a highly sensitive and specific assay for detecting sHLA-G from embryo culture media. S-41 S-42 S-43 Decidualization and Implantation S-44 Shurshalina, AV, Sukhikh, GT, Kogan, EA. Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia. CD138 in endometrium: chronic inflammation and receptivity. Bany, BM, Herington, JL, Miller, B, Allen, A. Southern Illinois University School of Medicine, Carbondale, Illinois, USA. Potential role of the immune system in modulating serine proteinase-28 (Prss28) and -29 (Prss29) expression mouse uteri during decidualization. McConaha, ME, Herington, JL, Eckstrum, K, Bany, BM. Southern Illinois University School of Medicine, Carbondale, Illinois, USA. Kazal type peptidase inhibitor gene expression is altered in the interleukin 15 mouse uterus during decidualization. Herington, JL1, Miller, B1, Steinle, JJ2, Bany, BM1. 1 Southern Illinois University School of Medicine, Carbondale, Illinois, USA, 2 University of Tennessee College of Medicine, Memphis, TN, USA. Microarray analysis of differential uterine gene expression between interleukin-15 wild-type and knockout mice. S-45 S-46 S-47 PREGNANCY BIOLOGY 22
Slide 23: S-48 Bondarenko, GI1, Durning, M1, Golos, TG1,2. 1 Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA, 2 Dept. of Comparative Biosciences, School of Veterinary Medicine, UW-Madison, Madison, WI, USA. Decidual vascularity and expression of vascular endothelial growth factor and its receptors throughout rhesus monkey gestation. Morales , DM, Markert, UR. University Hospital Jena, Jena, Thuringia, Germany. STAT3 ser727 phosphorylation in trophoblastic cells is induced by LIF but not via ERK1/2 activation. Edwards, AK1, van den Heuvel, MJ1, Croy, BA1,2, Tayade, C1,2. 1 University of Guelph, Guelph, ON, Canada, 2 Queen's University, Kingston, ON, Canada. Pro-angiogenic and anti-angiogenic factors and their relation to porcine pregnancy success or failure. Khachaturyan, L, Poehlmann, TG, Weber, M, Forti, ALL, Morales, DM, Fitzgerald, JS, Schleussner, E, Markert, UR. University Hospital Jena, Jena, Thuringia, Germany. Protein inhibitors of activated STATs (PIAS) control major trophoblastic functions. Racicot, KE, Schmitt, AP, Ott, TL. Pennsylvania State University, University Park, PA, United States. Characterization of an MX1-positive population of exosomes secreted by uterine glandular epithelial cells. Stamatkin, CW1, Roussev, RG1, Ramu, S1, Coulam, CB1,2, Barnea, ER1,2. 1 CARI /ProPREG Research Institute, Chicago, IL, USA, 2 The Society for the Investigation of Early Pregnancy (SIEP), Cherry Hill, NJ, USA. Preimplantation factor (PIF) binds to specific embryo sites to act as a rescue factor for embryo demise due to embryo toxic serum. Stamatkin , CW1, Ng, SC1, Roussev, RG1, Ramu, S1, Coulam, CB1,2, Barnea, ER1,2. 1 CARI/ProPREG Research Institute, Chicago, IL, USA, 2 The Society for the Investigation of Early Pregnancy (SIEP), Cherry Hill, NJ, USA. Preimplantation factor (PIF) suppresses natural killer (NK) cell cytotoxicity: suggested role in pregnancy loss management. Stamatkin, CW1, Roussev, RG1, Ramu, S1, Coulam, CB1,2, Barnea, ER1,2. 1 CARI/ProPREG Research Institute, Chicago, IL, USA, 2 The Society for the Investigation of Early Pregnancy (SIEP), Cherry Hill, NJ, USA. Endogenous PIF is essential for embryo development: anti-PIF mAb impairs embryonic development in vitro. Goodman, C1, Ramu, S1, Stamatkin, CW1, Roussev, RG1, Coulam, CB1,2, Barnea, ER1,2. 1 CARI /ProPREG Research Institute, Chicago, IL, USA, 2 The Society for the Investigation of Early Pregnancy (SIEP), Cherry Hill, NJ, USA. PIF ELISA - highly specific assay to detect pregnancy in serum: detection not affected by the presence of macrophage inflammatory protein – 1 – δ (MIP-1δ). S-49 S-50 S-51 S-52 S-53 S-54 S-55 S-56 Pregnancy Immunology S-57 Oliveira, LJ, Hansen, PJ. University of Florida, Gainesville, FL, USA. Phenotypic characterization of macrophages in the endometrium of the pregnant cow. Dambaeva, SV1, Durning, M1,2,3, Golos, TG1,2,3. 1 Depts of Comparative Bioscences , 2 Obstetrics and Gynecology, 3 National Primate Research Center, University of Wisconsin, Madison, WI, USA. Non-human primate decidual NK cells are a heterogenic population: the minor subset with CD56dimCD16- phenotype revealed a higher immunopotential in comparison to the widely proliferating CD56bright NK cells. S-58 23
Slide 24: S-59 Mjosberg, J1, Berg, G2, Ernerudh, J1, Jenmalm, MC1, Matthiesen, LS3. 1 AIR, Linkoping University, Linkoping, Sweden, 2 Div Obstetrics and Gynecology, Linkoping, Sweden, 3 Div Obstetrics and Gynecology, Helsingborg, Sweden. Enrichment of Foxp3+ Tregs and reduction of TH17 cells in human early pregnancy decidua indicate immunosuppressive T cell dominance. Mjosberg, J1, Svensson, J1, Johansson, E1, Hellstrom, L1, Casas, R2, Jenmalm, MC2, Boij, R3, Matthiesen, LS4, Berg, G5, Ernerudh, J1. 1 AIR, Linkoping University, Linkoping, Sweden, 2 Div of Pediatrics, Linkoping , Sweden, 3 Div Obstetrics and Gynecology, Jonkoping, Sweden, 4Div Obstetrics and Gynecology, Helsingborg, Sweden, 5 Div Obstetrics & Gynecology, University Hospital, Linkoping, Sweden. Systemic reduction of functionally suppressive CD4dim CD25high Foxp3+ Tregs in human second trimester pregnancy is induced by progestetrone and 17β-estradiol. Kalkunte, S1, Mselle, TF2, Norris, WE1, Wira, CR2, Sentman, CL2, Sharma, S1. 1 Women and Infants Hospital, Providence, RI, USA, 2 Dartmouth Medical School, Hanover, NH, USA. VEGF C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. Houser, BL, Nicotra, MN, Tilburgs, T, Strominger, J. Harvard University, Cambridge, MA, USA. Decidual macrophage populations at the maternal-fetal interface. Lee, HJ1, Park, DW2, Park, CW1, Song, IO1, Koong, MK1, Hong, SR3, Kwak-kim, J4, Yang, KM1,4. 1 Department of OB & Gyn, Cheil General Hospital & Women’s Healthcare Center, Kwandong University College of Medicine, Seoul, Korea, 2 Laboratory of reproductive biology, Cheil General Hospital & Women’s Healthcare Center, Kwangdong University College of Medicine, Seoul, Korea. Co-expression of TGF-β, CCL3 and CXCL12 in deciduas correlated to the number of decidual NK (dNK) cells. Wang, B1, Koga, K1, Osuga, Y1, Taketani, Y1, Mor, G2. 1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan, 2 Obstetrics Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. Indoleamine 2,3-Dioxygenase is induced by the TLR3 ligand poly(I:C) in human trophoblast cells and mechanism of induction. Ntrivalas, E, Levine, R, Gilman-Sachs, A, Kwak-Kim, J, Beaman, K. Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. a2V-ATPase expression in peripheral blood white blood cells of women of reproductive age. S-60 S-61 S-62 S-63 S-64 S-65 Male S-66 Shibahara, H1,2, Koriyama, J1,2, Asada, K1, Shiraishi, Y1,2, Hirano, Y1,2, Suzuki, M1,2. 1 Dept Ob/Gyn, School of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan, 2 Center for Reproductive Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan. Association of anti-sperm antibodies (ASA) with pregnancy loss in immunologically infertile couples. Hirai, S, Naito, M, Terayama, H, Qu, N, Itoh, M. Tokyo Medical University, Shinjuku Sshinjuku-ku, Tokyo, Japan. Terminal stage of murine autoimmune orchitis. Qu, N, Naito, M, Terayama, H, Hirai, S, Itoh, M. Tokyo Medical University, Shinjuku-ku, Tokyo, Japan. Preliminary characterization of relevant autoantigens in murine testicular autoimmunity. S-67 S-68 24
Slide 25: S-69 Terayama, H, Hirai, S, Naito, M, Qu, N, Kitaoka, M, Ogawa, Y, Itoh, M. Tokyo Medical University, Shinjuku, Tokyo, Japan. Proteome analysis of target antigens for testicular autoimmunity in mice. Hirano, Y1, 2, Shibahara, H1, 2, Koriyama, J1, 2, Shiraishi, Y1,2, Shimada, K1,2, Suzuki, M1,2. 1 Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke-shi, Tochigi, Japan, 2 Center for Reproductive Medicine, Jichi Medical University Hospital, Shimotsuke-shi, Tochigi, Japan. The incidence of anti-sperm antibodies in infertile couples with Chlamydia trachomatis infection. Koriyama, J1, 2, Shibahara, H1, 2, Shiraishi, Y1, 2, Hirano, Y1, 2, Suzuki, M1, 2. 1 Department of Obstetrics and Gynecology School of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan, 2 Center for Reproductive Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan. Toward standardization of the cut-off value of the directimmunobead test. S-70 S-71 Mucosal Immunity S-72 Ghosh, M1, Fahey, JV1, Cu-Uvin, S2, Shen, Z1, Mayer, K2, Wright, PF1, Wira, CR1. 1 Dartmouth Medical School, Lebanon, NH, USA, 2 Brown University, Providence, RI, USA. Cervical-vaginal secretions from HIV positive and HIV negative women have intrinsic anti-HIV activity. Haddad, SN, Wira, CR. Dartmouth Medical School, Lebanon, NH, USA. Signal transduction pathways involved in keratinocyte growth factor (KGF) regulation of mouse uterine epithelial cell innate immunity and the effects of estradiol. Aisemberg, J, Vercelli, C, Wolfson, M, Billi, S, Ribeiro, ML, Farina, M, Franchi, AM. CEFYBO (CONICET-UBA), Buenos Aires, Argentina. Protective effect of progesterone (P) on pregnancy loss due to LPS. Hickey, DK, Wira, CR. Dartmouth Medical School, Lebanon, NH, USA. Innate immunity in the mouse female reproductive tract (FRT) is influenced by selective estrogen receptor modulators (SERMs). Patel, MV, Ghosh, M, Shen, Z, Schaeffer, TM, Fahey, JV, Wira, CR. Dartmouth Medical School, Lebanon, NH, USA. Expression of intracellular antiviral genes in human uterine primary epithelial cells in response to stimulation by viral agonists. Reyes, L, Stevens, J, Vincent, C, Thomas, T, Canales, B, Brown, M. University of Florida, Gainesville, FL, USA. Shifts in vaginal microbial flora and local inflammatory response during urinary tract infections. Reyes, L1, Belanger, M1, Reinhard, M1, Lamont, R1, Progulske-Fox, A1, Brown, M1. 1 University of Florida, Gainesville, FL, USA. Porphyromonas gingivalis fimA is not associated with ability to colonize maternal and fetal tissues in a rodent model of infection. Ochiel, D1, Ghosh, M1, Fahey, J1, Kappes, J2, Ochsenbauer-Jambor, C2, Guyre, P1, Wira, C1. 1 Dartmouth Medical School, Lebanon, NH, USA, 2 University of Alabama, Birmingham, AL, USA. Uterine epithelial cell derived transforming growth factor β regulation of HIV-1 receptor expression on immature dendritic cells. S-73 S-74 S-75 S-76 S-77 S-78 S-79 25
Slide 26: S-80 Komine-Aizawa, S, Shibata, K, Shimotai, Y, Izumi, Y, Kuroda, K, Hayakawa, S. Nihon University School of Medicine, Tokyo, Japan. Forskolin induced differentiation of a human choriocarcinoma cell line BeWo decreases its susceptibility to H3N2 influenza virus. Arase, T, Maruyama, T, Uchida, H, Kajitani, T, Nishikawa, S, Oda, H, Kagami, M, Asada, H, Yoshimura, Y. Keio University Hospital, Shinjuku, Tokyo, Japan. UDP-glucose and its receptor P2RY14 as a novel innate immunity in the female reproductive tract. Hayakawa, S1, Trinh, QD1, 2, Aizawa, SK1, Shibata, T1, Shimotai, Y1, Kuroda, K1, Izumi, Y1, Mor, G3. 1 Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan, 2 Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, the University of Tokyo, 3 Yale University School of Medicine, New Haven, CT. H3N2 influenza A virus replicates in immortalized human first trimester trophoblast cell lines and induces their rapid apoptosis. Nazli, A, Chan, O, Kaushic, C. McMaster University, Hamilton, Ontario, Canada. HIV-1 exposure induces TNF-α production by polarized genital and intestinal epithelial monolayers leading to direct impairment of their barrier function. Aldo, PB1, Mulla, MJ1, Romero, R2, Mor, G1, Abrahams, VM1. 1 Yale University School of Medicine, New Haven, CT, USA, 2 The Perinatology Research Branch, NICHD/NIH, Detroit, MI, USA. TLR8 induces first trimester trophoblast apoptosis through an inflammatory mechanism. S-81 S-82 S-83 S-84 Regulation of Immune Function S-85 Xiaoyan Ying, XY, Jian Chen. The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, P. R of China. The effect of YiKang soup on LIF expression in human endometrium from women with unexplained fertility. Padua, MB, Hansen, PJ. University of Florida, Gainesville, FL, USA. Changes in expression of cell-cycle related genes in PC-3 prostate cancer cells caused by ovine uterine serpin. Atay, S, Gercel-Taylor, C, Kesterson, S, Taylor, DD. University of Louisville School of Medicine, Louisville, KY, USA. Suppression of NFκB by postmenopausal estrogen levels and its restoration by genistein. Faria, M., 1,2; Martucci, M. 2, Hoshida, M., 2, Ferro, E. 3, Paulesu, L. 4, Bevilacqua, E 2. 1 Ibirapuera University, Brazil; 2 University of São Paulo, Brazil; 3 Federal University of Uberlandia, Brazil, 4University of Siena, Italy. Spatiotemporal patterns of expression of MIF and receptors at the maternal-placental interface. S-86 S-87 S-88 26
Slide 27: SPONSORS American Autoimmune Related Diseases Association EMD Serono National Institutes of Health National Research Initiative Competitive Grant no. 2007-35203-18070 from the USDA Cooperative State Research, Education, and Extension Service University of Florida – Agricultural Experiment Station University of Florida – College of Veterinary Medicine University of Florida – Health Science Center University of Florida – Office of Research VisualSonics Women and Infants Hospital and Surendra Sharma 27