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History of Niacinamide 

 

 
 
Tags:  acne complex  cosmetic dermatology  dermatology courses 
Views:  203
Published:  October 27, 2011
 
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Slide 1: Niacinamide - A New Vitamin for Anti-Ageing Skin Care Products “Niacinamide is a promising additive in anti-ageing moisturiser formulations designed to enhance cutaneous functioning.” Zoe Diana Draelos, MD Cosmetic Dermatology, September 1999 The last five years have seen rapid advances in the application of vitamins to anti-ageing skin care formulations. The skin repair benefits of panthenol (pro-vitamin B5), as well as its humectant properties, are well known. Vitamin E is also a very well established skin care ingredient, with proven benefits. Recently, there have been a lot of new products containing retinol (vitamin A) and vitamin C. With research into vitamins intensifying, niacinamide (vitamin B3) has now been identified as a valuable new vitamin for anti-ageing skin care products. The History of Niacinamide Niacinamide was first isolated from several natural sources, including rice bran and yeast, at the start of the 20th Century. It was not until 1937, however, that it was shown to be an important dietary vitamin. Many years of research into the disease pellagra (italian for pelle agra, or ‘rough skin’), which has dermatitis as one of its main symptoms, eventually showed that it could be cured by the addition of niacinamide to the diet. Niacinamide then became known as vitamin PP (‘Pellagra Preventing’) and later vitamin B3. Niacinamide in the Body Niacinamide is part of the B-complex family of vitamins, which can in general be described as metabolic catalysts or coenzymes. Specifically, niacinamide is a building block for coenzyme I (NAD) and coenzyme II (NADP), which play an essential role in cellular energy production. As cells get older, the levels of coenzyme I and coenzyme II go down, and the cells have less energy. This makes them less able to perform essential functions, like the removal of old or damaged components and their replacement with new components (i.e. cell turnover) as well as defence against environmental damage. Niacinamide as an Anti-Ageing Ingredient Niacinamide has been known for some time to give a number of important benefits when applied to the skin. These include an anti-inflammatory action, causing it to be used in a commercial anti-acne preparation, and the ability to increase the level skin lipids. In recent research, valuable benefits have also been demonstrated for niacinamide in cosmetic antiageing products. It has been shown to significantly improve skin texture and to reduce the appearance of age spots. Niacinamide has the advantage of being inherently stable, allowing it to be combined with other vitamins to give enhanced effects and multiple benefits. Combined with panthenol and vitamin E in a moisturiser base, niacinamide has been shown to increase the exfoliation rate of the skin while simultaneously enhancing its barrier properties. This range of benefits, as well as its stability and excellent skin compatibility, make niacinamide an important new anti-ageing vitamin.

   
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