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Slide 1: CDD aids Collaborations Result New leads reveal known drugs that reverse chloroquine resistance © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Slide 2: Yes We Can! © 2009 Collaborative Drug Discovery, Inc. © 2010 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Slide 3: CDD Successfully Builds Collaborative Drug Discovery Communities • DDT, 2009 (14: 261-270): • $1.89M Tuberculosis B&MGF Project • >5 Years CDD SaaS in the Cloud • Thousands of scientists engaged: © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Slide 4: CDD Platform • Modules: • CDD Vault – Secure place for private data – private by default • CDD Collaborate – Selectively share subsets of data • Datasets: • CDD Public – expanding public data sets • • • published compounds data from community members vendor libraries • Unique to CDD – simultaneously query your private data, collaborators’ data, & public data © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
Slide 5: CDD Database for Your Private Data © 2009 Collaborative Drug Discovery, Inc. Copyright © 2010 All Rights Reserved Collaborative Drug Discovery Archive, Mine, Collaborate
Slide 6: with single login to multiple CROs/Biotech groups Collaborate Mode 1 – Big Pharma Consolidated CDD DB P ro je ct Company A ct A roje P Pr o je ct C Pro j ect B D Collaborator 1 Collaborator 2 Collaborator 3 Collaborator 4 Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc. Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
Slide 7: Collaborate Mode 2 – Peer-to-Peer: Any Data via Any Query Can Be Securely Shared CDD DB group 1 CDD DB group 2 CDD DB group 3 CDD DB group 4 © 2009 Collaborative Drug Discovery, Inc. Copyright © 2010 All Rights Reserved Collaborative Drug Discovery Archive, Mine, Collaborate
Slide 8: Use CDD Vault™, Collaborate™, Public™ for Global R&D Community New Types of Offerings for a Rapidly Changing Industry • CDD Community: tap into global R&D via “crowd-sourcing” • CDD Alliance: better management of your collaborations • CDD Customize: fast, good, and cost-effective = agile © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
Slide 9: Acknowledgements • Sean Ekins, PhD, DSc (Collaborations Director – Philadelphia Office) • Pfizer, Lilly, Concurrent Pharmaceuticals, GeneGo • Moses Hohman, PhD (VP Software Development) • Northwestern Assoc. Director of Bioinformatics, Thoughtworks, Inc., U of Chicago (PhD), Harvard (magna cum laude, Physics) • Sylvia Ernst, PhD (Senior Director Community Growth – Northwest Office) • Accelrys-Scitegic, MDL • Andrea Barry (Senior Director Business Dev – N. Carolina Office) • Accelrys-Scitegic, MDL • Kellan Gregory (Head Community Interests Group) • Anna Spektor (Community Advocate, ex-IDBS) • Eli Lilly & Co. • Bill & Melinda Gates Foundation • Initial TB pilot laboratories • CDD Researcher Community • 1000s of CDD collaborators from academia, foundations and industry © 2009 Collaborative ChemAxon Tools • Drug Discovery, Inc. (under the hood) Copyright © 2010 All Rights Reserved Collaborative Drug Discovery Archive, Mine, Collaborate
Slide 10: Answers for Our Field • Start with Strong Mission & Values • Neglected disease and commercial disease are both core components • Collaborative culture – share successes and failures, as much as possible • Tap leading community expertise with industry focused process • Do Groundbreaking Work • Revolutionary approaches to solving critical health problems • Imagine what would be possible in an ideal world, practically implement • Discover drugs while changing the nature of the game • What if…you had a magic wand? © 2009 Collaborative Drug Discovery, Inc. Copyright © 2010 All Rights Reserved Collaborative Drug Discovery Archive, Mine, Collaborate
Slide 11: Archive, Mine, Collaborate® CDD Collaborative Drug Discovery, Inc. Burlingame, CA www.collaborativedrug.com Barry A. Bunin, PhD CEO & President © 2009 Collaborative Drug Discovery, Inc. info@collaborativedrug.com Archive, Mine, Collaborate