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Slide 1: Principal Investigator/Program Director (Last, First, Middle): Principal Investigator/Program Director (Last, First, Middle): Kardon, Randy, H BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Randy H. Kardon eRA COMMONS USER NAME kardon INSTITUTION AND LOCATION EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE (if applicable) YEAR(s) FIELD OF STUDY Professor of Ophthalmology Director of Iowa City VA Center of Excellence Director of Neuro-ophthalmology University of Iowa, Iowa City, Iowa University of Iowa, Iowa City, Iowa Gundersen Clinic & Lutheran Hospital, University of Iowa, Iowa City, Iowa University of Iowa, Iowa City, Iowa University of Iowa, Iowa City, Iowa A. Positions and Honors. B.S. M.D./Ph.D. Intern Fellowship Residency Fellowship 1975 1982 1982-1983 1983-1984 1984-1987 1987-1989 General Science Pharmacology Medical Internship Research Fellowship Ophthalmology Neuro-ophthalmology Positions and Employment 1989 - 1994 Assistant Professor of Ophthalmology University of Iowa College of Medicine, Iowa City, IA 1989 - Present Staff, Ophthalmology, Surgery Division, Department of Veterans Affairs Medical Center, Iowa City, I 1990 - 1999 Research Associate, Career Development Award Department of Veterans Affairs Medical Center, Iowa City, IA 1994 - 2004 Associate Professor of Ophthalmology University of Iowa, College of Medicine, Iowa City, IA 2002 – Present Director of Neuro-ophthalmology, Department of Ophthalmology 2004 – Present Professor with Tenure of Ophthalmology University of Iowa College of Medicine, Iowa City, IA 2007 – Present Pomerantz Family Chair of Ophthalmology Other Experience and Professional Membership 1997 Editorial Board, Journal of Clinical Neuro-ophthalmology 1995 - 1999 Fight For Sight Fellowship Grant Review Committee 1999 – Present Scientific Director for Fight For Sight Grant Program 2001 – Present Reviewer for Neuroscience VA Merit Review Grant committee and Chair of Visual Rehab Research and Development Grant committee (2008) 2006 – Present Reviewer for NEI Grant Committee on Retinopathy Studies CB-G90 2008– Present Editorial Board, Archives of Ophthalmology Honors and Awards: 1987-89 Fight for Sight Research Fellowship Grant 1987-89 National Society to Prevent Blindness Burroughs-Wellcome Fellowship 1990-99 Recipient of Career Development Award (VAMC) 1991 Recipient of the Charles D. Phelps Research Award PHS 398/2590 (Rev. 09/04) Page Continuation Format Page
Slide 2: Principal Investigator/Program Director (Last, First, Middle): 1993-Present Listed in The Best Doctors in America 1994 Recipient of Carver Trust Fund Research Seed Grant 1994 Recipient of Research to Prevent Blindness James S. Adams Scholar Award 1994 Recipient of University of Iowa College of Medicine Collegiate Teaching Award 1995 Recipient of the American Academy of Ophthalmology Honor Award 1995 Educational Grant “A Digital Video Library of Eye Movement and Pupil Disorders” ($5,000) 1996 Senior Honor Award, American Academy of Ophthalmology 1998 Recipient of Research to Prevent Blindness Lew R. Wasserman Scholar Award 2006 Senior Achievement Award, American Academy of Ophthalmology 2007 Awarded the Pomerantz Family Chair in Ophthalmology A. Selected peer-reviewed publications 50/135 (in chronological order). 1. Kardon RH, Kirkali PA, Thompson HS: Automated pupil perimetry. Pupil field mapping in patients and normal subjects. Ophthalmol 98:485-496, April 1991 2. Kardon RH, Haupert CL, Thompson HS: The relationship between static perimetry and the relative afferent pupillary defect. Am J Ophthalmol 115:351-356, March 1993 3. Zabriskie N, Kardon RH: The Pupil Photostress Test. Ophthalmology 101(6), 1122-30, 1994 4. Kawaski A, Moore P, Kardon RH: Variability of the relative afferent pupillary defect. Am J Ophthalmol 120(5):622-33, November 1995 5. Kawasaki A, Moore P, Kardon RH: Long-term fluctuation of relative afferent pupillary defect in subjects with normal visual function. Am J Ophthalmol 122(6), 875-82; December 1996 6. Mizener JB, Kimura AE, Adamus G, Thirkill CE, Goeken JA, Kardon RH: Autoimmune Retinopathy in the absence of cancer. Am J Ophthalmol 123(5):607-18;May 1997 7. Wilhelm H, Kardon RH: The pupillary light reflex pathway. Neuro-ophthalmol 17(2):59-62;1997 8. Donahue SP, Moore P, Kardon RH: Automated pupil perimetry in amblyopia: generalized depression in the involved eye. Ophthalmology. 104(12):2161-7, December 1997 9. Kardon RK, Corbett JJ, Thompson HS: Segmental denervation and reinnervation of the iris sphincter as shown by infrared videographic transilluminatiohn. Ophthalmol 105(2):313-321;February 1998 10. Lagreze WDA, Kardon RH: Correlation of relative afferent pupillary defect and estimated retinal ganglion cell loss. Graefes Archive for Clinical & Experimental Ophthalmology. 236(6):401-404, June 1998 11. Hong, S, Narkiewicz, J, Kardon RH: Comparison of Pupil Perimetry and Visual Perimetry in Normal Eyes: Decibel Sensitivity and Variability. Invest Ophth. Vis Sci April 2001 12. Kawasaki A, Kardon RH: Disorders of the Pupil. Neuro-ophthalmol 14(1); 149-168, March 2001 13. Oh KT, Forlk JC, Maturi RK, Moore P, Kardon RH: Multifocal Electroretinography in Multifocal Choroiditis and the Multiple Evanescent White Dot Syndrome. Retina 21(6);581-589, 2001 14. Lee AG, Golnik K, Kardon R, Wall M, Eggenberger E, Yedavally S: Sleep Apnea and Intracranial Hypertension in Men. Ophthalmology 109 (3); 482-5, 2002. 15. Grozdanic S., Sakaguchi D.S., Kwon Y.H., Kardon R.H. and Sonea I. M. Characterization of the pupil light reflex, electroretinogram and tonometric parameters in healthy rat eyes. Current Eye Research 25(2):69-78; 2002. 16. Hayreh SS, Zimmerman B, Kardon RH: Visual improvement with corticosteroid therapy in giant cell arteritis: Report of a large study and review of literature. Acta Ophthalmol Scand 80; 355-67, 2002. 17. Eggenberger E, Golnik K, Lee A, Santos R, Suntay A, Satana B, Vaphlades M, Stevens C, Kautman D, Wall M, Kardon R: Prognosis of ischemic internuclear ophthalmoplegia. Ophthalmol 109(9);1676-8, 2002. 18. Bergamin O, Kardon RH: Greater pupillary escape differentiates central from peripheral visual field loss. Ophthalmol 109(4); 771-780, April 2002 19. Bergamin O, Zimmerman MB, Kardon RH: Pupil light reflex in normal and diseased eyes. Diagnosis of visual dysfunction using waveform partitioning. Ophthalmol 110(1); 106-14, 2003. 20. Bergamin O, Kardon RH: Latency of the pupil light reflex : Sample rate, stimulus intensity, and variation in normal subjects. Invest Ophthalmol Vis Sci 44(4) 1546-54, 2003. 21. Grozdanic S., Betts DM, Sakaguchi DS, Kwon YH, Kardon RH, Sonea IM: Temporary elevation of the intraocular pressure by cauterization of vortex and episcleral veins in rats causes functional deficits in the retina and optic nerve. Exp Eye Res. 77(1):27-33, 2003. 22. Grozdanic S., Betts DM, Allbaugh RA, Sakaguchi DS, Kwon YH, Kardon RH, Sonea IM: Characterization of the pupil light reflex, electroretinogram and tonometric parameters in healthy mouse eyes. Curr Eye Res. 26(6):371-8, 2003. PHS 398/2590 (Rev. 09/04) Page Continuation Format Page
Slide 3: Principal Investigator/Program Director (Last, First, Middle): 23. Grozdanic S., Betts DM, Sakaguchi DS, Kwon YH, Kardon R., Sonea IM: Functional and morphological characterization of retina and optic nerve in laser-induced rat model of chronic ocular hypertension. Invest Ophthalmol Vis Sci. 44(6):2597605, 2003. 24. Grozdanic SD, Betts DM, Sakaguchi DS, Allbaugh RA, Kown YH, Kardon RH: Laser-induced mouse model of chronic ocular hypertension. Invest Ophthalmol Vis Sci 44(10):4337-46, 2003 25. Grozdanic SD, Sakaguchi DS, Kwon, YH, Kardon RH, Sonea IM: Functional Characterization of retina and optic nerve after acute ocular ischemia in rats. Invest Ophthalmol Vis Sci 44(6):2597-605, 2003 26. Grozdanic SD, Kwon YH, Sakaguchi Ds, Kardon RH, Sonea IM: Functional evaluation of retina and optic nerve in the rat model of chronic ocular hypertension. Exp Eye Res 79(1):75-83, 2004 27. Lee AG, Chau FY, Golnik, KC, Brazis PW, Wall M, Kardon RH: Evaluation of Isolated Optic Atrophy: An Update and Review. Comprehen Ophthalmol Update 5(6): 297-304, December 2004 28. Kwon YH, Pereira MLM, Anderson SC, Young IK, Kardon RH: Quantitative correlation of elevated intraocular pressure with relative afferent pupillary defect change in unilateral glaucoma. Acta Ophthalmol Scan 83(1): 127-9, February 2005 29. Kardon R: Are we ready to replace cocaine with apraclonidine in pharmacologic diagnosis of Horner syndrome? J Neuro-Ophthalmol, 25(2); 69-70, 2005 30. Kardon, R, Susan Anderson, Aki Kawasaki, Sylvain Crippa: The Pupil Response to Large Regional Stimuli in Patients with Focal Visual Field Loss. Neuro-Ophthalmology, 29:143-147, 2005 31. Nowomiejska,K, Vonthein, R, Paetzold, J, Zagorski, Z, Kardon, R, Schiefer, U: Comparison between semiautomated kinetic perimetry and conventional Goldmann manual kinetic perimetry in advanced visual field loss. Ophthalmology, 112(8):1343-54, 2005 August 32. Abramoff, MD, Kwon, YH, Ts’o, D, Soliz, P, Zimmerman, B, Pokorny, J, Kardon, RH: Visual stimulus-Induced changes in human near-infrared fundus reflectance. IOVS, Vol 47, No.2, 715-721,2006 February. 33. Ostojic J. Sakaguchi DS. de Lathouder Y. Hargrove MS. Trent JT 3rd. Kwon YH. Kardon RH. Kuehn MH. Betts DM. Grozdanic S: Neuroglobin and cytoglobin: oxygen-binding proteins in retinal neurons. Investigative Ophthalmology & Visual Science. 47(3):1016-23, 2006 Mar 34. Hood DC, Anderson SC, Wall M, Kardon RH: Structure versus Function in Glaucoma: An Application of a Linear Model. Invest Ophthalmol Vis Sci 48(8):3662-8, 2007 35. Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res. 2007 Aug 21 36. Kawasaki A, Kardon RH. Intrinsically Photosensitive Retinal Ganglion Cells. J Neuroophthalmol. 2007 Sep;27(3):195-204. 37. Hood DC, Anderson S, Rouleau J, Wenick AS, Grover LK, Behrens MM, Odel JG, Lee AG, Kardon RH. Retinal Nerve Fiber Structure versus Visual Field Function in Patients with Ischemic Optic Neuropathy A Test of a Linear Model. Ophthalmology. 2007 Sep 15 38. Grozdanic SD, Matic M, Sakaguchi DS, Kardon RH. Evaluation of retinal status using chromatic pupil light reflex activity in healthy and diseased canine eyes.Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5178-83. 39. Grozdanic SD, Matic M, Betts DM, Sakaguchi DS, Kardon RH.Recovery of canine retina and optic nerve function after acute elevation of intraocular pressure: implications for canine glaucoma treatment.Vet Ophthalmol. 2007 NovDec;10 Suppl 1:101-7. 40. Wall M, Brito CF, Woodward KR, Doyle CK, Kardon RH, Johnson CA: Total deviation probability plots for stimulus size v perimetry: a comparison with size III stimuli. Arch Ophthalmol 126(4): 473-479, 2008 41. Koczman JJ, Rouleau J, Gaunt M, Kardon RH, Wall M, Lee AG. Neuro-ophthalmic sarcoidosis: the University of Iowa experience. Semin Ophthalmol. 2008. May-Jun;23(3):157-68. 42. Reede DL, Garcon E, Smoker WR, Kardon R. Horner's syndrome: clinical and radiographic evaluation. Neuroimaging Clin N Am. 2008 May;18(2):369-85, 43. Garvin MK, Abramoff MD, Kardon R, Russell SR, Wu X, Sonka M. Intraretinal layer segmentation of macular optical coherence tomography images using optimal 3-D graph search. IEEE Trans Med Imaging. 2008 Oct;27(10):1495-505. 44. Costello F, Hodge W, Pan YI, Metz L, Kardon RH. Retinal nerve fiber layer and future risk of multiple sclerosis. Can J Neurol Sci. 2008 Sep;35(4):482-7. 45. Ostojić J, Grozdanić SD, Syed NA, Hargrove MS, Trent JT 3rd, Kuehn MH, Kwon YH, Kardon RH, Sakaguchi DS. Patterns of distribution of oxygen-binding globins, neuroglobin and cytoglobin in human retina. Arch Ophthalmol. 2008 Nov;126(11):1530-6. PHS 398/2590 (Rev. 09/04) Page Continuation Format Page
Slide 4: Principal Investigator/Program Director (Last, First, Middle): 46. Schallek JB, Kardon RH, Kwon YH, Abramoff MD, Soliz P, Tso D. Stimulus-Evoked Intrinsic Optical Signals in the Retina: Pharmacological Dissection Reveals Outer Retinal Origins. Invest Ophthalmol Vis Sci. 2009 May 6. 47. Schallek JB, Li H, Kardon RH, Kwon YH, Abramoff MD, Soliz P, Ts'o DY. Stimulus-Evoked Intrinsic Optical Signals in the Retina: Spatial and Temporal Characteristics. Invest Ophthalmol Vis Sci. 2009 May 6. 48. Hood DC, Anderson SC, Wall M, Raza AS, Kardon RH. A Test of a Linear Model of Glaucomatous StructureFunction Loss Reveals Sources of Variability in Retinal Nerve Fiber and Visual Field Measurements. Invest Ophthalmol Vis Sci. 2009 May 14. 49. Wall M, Johnson CA, Kardon RH, Crabb DP. Use of a continuous probability scale to display visual field damage. Arch Ophthalmol. 2009 Jun;127(6):749-56. 50. Kardon R, Anderson SC, Damarjian TG, Grace EM, Stone E, Kawasaki A. Chromatic Pupil Responses Preferential Activation of the Melanopsin-mediated versus Outer Photoreceptor-mediated Pupil Light Reflex. Ophthalmology. 2009;116(8):1564-73. Ongoing Research Support 2009-2014 Department of Veterans Affairs Center of Excellence for “The Prevention and Treatment of Visual Loss”. Role: Principle Investigator and Director of Center 2009-2113 Veterans Administration Rehab Grant “Cholinergic Drugs For Reversal Of Visual Deficits In Glaucoma” Goal is to show that topical and systemic cholinergic agents reduce optic nerve damage and in some cases, reverse it in a dog form of inherited progressive glaucoma. Role: PI 2009-2012 1R01EY018853-01A2 NIH (NEI) “Focal Structure-Function Relationships in Macular Layers from 3D Spectral OCT” Goal is to develop image analysis tools to relate the structure and function in layers of the retina using volume optical coherence tomography of the macula in human retina. Role: Co-PI 2005-2008 R01EY017066-01, NIH (NEI) “Low-cost, portable, computer assisted imaging for diabetic retinopathy” Michael Abramoff(PI) Goal is to develop software feature analysis of retinal images from low cost retinal cameras for diagnosis and monitoring of diabetic retinopathy (telemedicine) Role: Co-Investigator 2007-2010 Veterans Administration Rehab Grant “Growth Factor Treatment of Visual Loss in Comprehensive Optic Nerve Injury”Goal is to use intravitreal sustained release growth factors to reduce visual loss from compressive optic neuropathy model in dogs. Role: Principle Investigator 2005-2008 Veterans Administration Rehabilitation Research and Development Grant, Treatment of Visual Loss In Glaucoma and Ischemia with Neurotrophic Growth Factors. Goal is to use intravitreal sustained release growth factors to reduce visual loss from glaucoma model in dogs. Role: Principle Investigator 2008-2011 Veterans Administration Rehab Grant Randy Kardon(PI). Rehabilitation of Glaucoma Using ComputerAnalyzed Eye Images.Goal is to develop software feature analysis of optic nerve images from low cost retinal cameras for diagnosis, staging and monitoring of glaucoma (telemedicine) Role: Principle Investigator 2008.2011 Department of Defense (DOD) Peer Reviewed Medical Research Program (PRMRP PR064674) Treatment of Laser-Induced Retinal Injury and Visual Loss Using Sustained Release of Intra-vitreal Neurotrophic Growth Factors. Goal is to use intravitreal sustained release growth factors to reduce visual loss from laser-induced retinal damage in dogs Role: Principle Investigator D. Time and Effort (8/8 VA appointment 40hrs/week, University joint appointment 10hrs/week) Research 50% Clinical 30% Teaching/mentoring15% Administration 5% PHS 398/2590 (Rev. 09/04) Page Continuation Format Page